DDL2023 Programme

08:00

Association of Inhalation Toxicologists Workshop Registration and Refreshments

09:00 - 12:00

The Association of Inhalation Toxicologists –  Morning Workshop at DDL2023

Pre-clinical development – Back to Basics

**You must register to attend this event – registration costs £50 and is free for students**

For full details, and to register to attend, please follow this link.

10:00

DDL2023 Registration and Refreshments

12:00 - 13:00

Networking Lunch in the Exhibition Hall and Poster Hall

Network with delegates and view the industry exhibition.

Visit the conference posters exhibition on Level 0.

(Lunch is served on both levels)

12:00 - 13:00

The DDL New Researcher Networking Lunch

Lunchtime Professional Speed Networking – for new and early career scientists and PhD students only.

Lowther Meeting Room, Level -1

For full details of this event and to book, please use this link

13:00 - 13:20

Conference Opens

Welcome by Gary Pitcairn, DDL Conference Chair

 

13:20 -13:50

Of mice and men: Correlation and clinical relevance of animal models and non-clinical tests for inhaled pharmaceuticals

The DDL Annual Lecture

The DDL Lecture is a prestigious accolade bestowed on individuals who have contributed much to the field of respiratory science.

Awarded to:

Daniela Traini, Woolcock Institute of Medical Research

13:50 - 13:55

SESSION 1 – DIGITAL TECHNOLOGIES

13:55 - 14:20

The impact of Data science and artificial intelligence in the pharmaceutical industry

José Sánchez, AstraZeneca

 

14:20 - 14:35

Inhaler Technique mastery; focus on LEARNING rather than TRAINING

Mark Sanders, University of Hertfordshire

14:35 - 15:00

Digital technologies to improve adherence: Limitations and opportunities

Rob Horne, UCL School of Pharmacy, University College London

 

15:00 - 15:15

European Respiratory Society Clinical Research Collaboration CONNECT. Moving multiple digital innovations towards connected respiratory care: Addressing the over-arching challenges of whole systems implementation

Hilary Pinnock, The University of Edinburgh

15:15 - 16:35

Refreshment Break 

Explore the exhibition stands and network with delegates

Manned Poster Session – speak to the conference poster authors in this manned poster session.  The poster exhibition is on Level 0.

Poster presenters will be interviewed by the DDL Judges to be considered for the Best Academic and Best Industry Poster at DDL2023.

16:35 - 16:40

SESSION 2 – NOVEL FORMULATIONS AND PROCESS TECHNOLOGY

16:40 - 17:05

Inhalable RNA formulations based on pulmonary surfactant and repurposed cationic amphiphilic drugs

Koen Raemdonck, Ghent University

17:05 - 17:30

Nanoparticle design for improved delivery of antimicrobials to the lungs

Hanne Mørck Nielsen, University of Copenhagen

17:30 - 19:30

Welcome Drinks Reception

Network across the conference centre, with drinks, snacks and entertainment on two floors.

17:30 - 18:30

The New Researcher Network

Show and Tell Event – for new and early career researchers and PhD Students only.

Lowther Meeting Room, Level -1

Join us for a lively discussion where our guests will delve into their professions.

With invited speakers:

Dr Alison Lansley – University of Brighton and Dr Floris Grasmejer – University of Groningen & PureIMS

08:00

Registration and Refreshments

09:00 - 09:05

Winner of The DDL2023 Emerging Scientist Award Announced

The winner of this award will be announced live on stage and will present their research.

This award recognises significant scientific accomplishment or innovation during the early stages of an individual’s career in inhalation science.

09:05 - 09:35

The DDL2023 Emerging Scientist

Winner’s Presentation

09:35 - 09:40

SESSION 2 – NOVEL FORMULATIONS AND PROCESS TECHNOLOGY CONTINUED

09:40 - 10:05

Formulation and Chemistry Strategies to Overcome Pulmonary Drug Delivery Barriers

David Cipolla, Insmed Incorporated

10:05 - 10:20

Enoximone and cyclodextrins: novel formulations for the treatment of pulmonary pathologies

Chiara Migone, University of Pisa

10:20 - 11:30

Refreshment Break

Explore the exhibition stands, view the posters on Level 0, and network with delegates

11:30 - 11:45

Plume Geometry: examination of processing schemes and inter-analyst variability…We Can Do Better!

Christopher Gruenloh, PPD, Part of Thermo Fisher Scientific

11:45 - 12:00

A Multi-Physics Theoretical and CFD Approach, To Predict Low-GWP pMDI Spray Characteristics, Inside USP-IP Geometry

Hossain Chizari, Kindeva Drug Delivery

12:00 - 12:15

Steady or not? Using realistic, transient aerosol parameters to predict lung deposition

Maximilian Grill, Ebenbuild GmbH

12:15 - 12:30

Reducing Time Requirements for Morphologically Directed Raman Spectroscopy Based In Vitro Bioequivalence Studies via Advanced Optimisation of Analysis Methods

Benjamin Stafford, Intertek Melbourn

12:30 - 14:05

Networking Lunch in the Exhibition Hall and Poster Hall

Network with delegates, visit the exhibition stands and view the conference posters on Level 0

(Lunch is served across the two floors)

14:05 - 14:10

SESSION 3: The Pat Burnell Young Investigator Award

Finalists present their work and are judged by the DDL Organising Committee

The winner of the competition will be announced at the Awards Ceremony on Thursday evening

This award recognises the vision of Pat Burnell and has been designed to encourage junior researchers from either academia or industry to present their work at the DDL Conference.

14:10 - 14:25

Development of pulmonary formulations with gallium siderophores against Aspergillus fumigatus lung infections

Brunella Grassiri, University of Pisa

14:25 - 14:40

Predicting Systemic Exposure to Inhaled Drugs using a Simplified Regional Deposition and Pharmacokinetic Method

Scott Tavernini, University of Alberta

14:40 - 14:55

Enhanced Lung Delivery of mRNA Using Nebulized Lipid Nanoparticles

Ricardo Velez, Hovione

14:55 - 15:10

Amorphous Spray Dried Microparticles for Nasal Delivery: Tackling Solubility Challenges while Targeting Systemic Nasal Absorption

Patrícia Henriques, Hovione

15:10 - 15:25

Developing a Combined Calu-3 Barrier and Smooth Muscle Model of the Airways Utilising a Perfused Microphysiological System

Adeel Ahmed, University of Hertfordshire

15:25 - 16:25

Refreshment Break

Explore the exhibition stands, view the conference posters and network with delegates

16:25 - 16:30

SESSION 4 – EMERGING THERAPEUTICS

16:30- 16:55

The intranasal delivery of stem cell-based therapies as an emerging approach to treating lung disorders

Chrishan Samuel, Monash University

16:55 - 17:10

A lung-to-heart nanomedicine for chronic heart failure

Eride Quarta, University of Parma

17:10 - 17:25

Impact of protein aggregation on the immunogenicity of a human monoclonal antibody following pulmonary administration in mice

Rita Vanbever, Université catholique de Louvain

17:25 - 20:00

DDL2023 Award Ceremony Drinks Reception

The Cromdale Hall, (EICC)

Co-sponsored by Intertek Melbourn and Koura Global

The DDL Organising committee will announce the winner of the Pat Burnell Young Investigator Award, the Best Industrial Poster and the Best Academic Poster, at our networking awards ceremony.

01

Evaluation of the anticancer activity of solid dispersions of chloramphenicol derivative with commonly used inhaled excipients

Arwa Al Khatib, University of Reading

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02

Effects of cyclodextrins and human serum albumin on solubilising and aerosolising cannabidiol

Wai Ting Tai, The University of Sydney

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03

In Vivo Biodistribution of Inhaled Colistin-Endolysin Combination

Pengfei Zhang, The Chinese University of Hong Kong

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04

Inhaled Lacticaseibacillus rhamnosus-derived postbiotics as novel strategy to tackle Pseudomonas aeruginosa lung infection in cystic fibrosis

Marta Bianchi, University of Pisa

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05

Pulmonary delivery of Lactobacillus rhamnosus GG with vibrating mesh and jet nebulisers

Alex Byun, The University of Sydney

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06

Novel Inhalable Formulations for Targeted Delivery of Antibiotics to the Lung: A Response to the Global Tuberculosis Commitment

Sharareh Salar-Behzadi, Research Center Pharmaceutical Engineering (RCPE) GmbH

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07

Design of in vitro lung mucus-microbiota model to assess efficacy of inhaled antibiotics

Mahmoud H. Abu Elella, University of Reading

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08

Advancing nasal formulation testing: What equipment to use for delivered dose assessment?

Niklas Baltz, Kiel Univeristy

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09

Potential use of cannabinoids to combat against methicillin-resistant Staphylococcus aureus pneumonia: A pre-formulation study

Pancy Tsz Hei Kwong, The University of Sydney

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10

In Silico Modelling to Aid Product Development Strategies for Low Global Warming Potential Metered Dose Inhalers

Neha Patel, Kindeva Drug Delivery

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11

A Novel Microdosing Device for Precise Dosing in Inhalation Therapy

Alessia Pietropaolo, University of Parma

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12

Development of a Direct in Vessel Aerosol Collection Apparatus for Dissolution Testing

Mårten Svensson, Emmace Consulting AB 

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13

A device screening method for predicting delivery of inhaled mRNA via a nebuliser

Imco Sibum, Resyca B.V.

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14

The use of microfluidic method to prepare PEG12KL4/siRNA complexes for pulmonary delivery

Cheng Ma, The University of Hong Kong

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15

Impact of the Aptar Digital Health (ADH) respiratory platform on adult asthma healthcare cost

Akash Bijlani, Aptar Digital Health

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16

A Novel Mathematical Model to Predict The Particle Size Distribution of pMDI Aerosols

Hossain Chizari, Kindeva Drug Delivery

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17

Assessment of Aerosol Characterisation and Delivery Performance of a Solution Using Different Configurations of a Breath-Actuated Mesh Nebuliser

Yuan-Ming Hsu, HCmed Innovations

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18

Inhaler Design Considerations for Humidity Exposed Spray Dried Vaccine Powders

Varsha Singh, McMaster University

19

Comparing The Aerosol Front Velocity Of Dry Powder Inhalers With The Corresponding Velocity Of Pressurised Metered Dose Inhalers And Soft Mist Inhalers

Herbert Wachtel, Boehringer Ingelheim Pharma GmbH & Co. KG

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20

Assessment of the Delivery Performance of a Novel Soft Mist Inhaler Using a Pre-Filled Syringe Based Container Closure System

Pragathi Gurumurthy, Resyca B.V.

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21

Influence of Fluid Physiochemical Properties on Aerosolization Performance of a Novel Soft Mist Inhaler

Hui Xin Ong (YY), Macquarie Medical School

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22

Solving AeroChamber alert whistle inconsistencies

Mark Sanders, University of Hertfordshire

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23

Evaluating the Impact of a Volume and Flow Resistance Compensator on Flow Rate Rise-Time Profiles in Dose Uniformity Testing and Aerodynamic Particle Size Distribution Measurement Apparatus for a Dry Powder Inhaler

Ben Bradley, Copley Scientific

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24

Experimental Evaluations of Internal Losses in ‘Miller’ Mixing Inlet (MI): Part 2 – Dry Powder Inhaler (DPI) Testing for Aerodynamic Particle Size Distribution (APSD)

Mårten Svensson, Emmace Consulting AB 

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25

Pulmonary delivery of lysostaphin with a vibrating mesh nebulizer and soft mist inhaler

Sharon Leung, The Chinese University of Hong Kong

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26

Assessment of pulmonary delivery of Plasminogen for ARDS local treatment

Lucia Vizzoni, University of Pisa

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27

Inhaled biologics: from nebules to SMIs – Dornase alfa in MRX004

Dylan Antoniak, Merxin Ltd

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28

Transitioning pMDIs to SMIs: salbutamol as a case study

Dylan Antoniak.,Merxin Ltd

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29

Pathway of Construction and Characterization of a Salbutamol Sulphate HFA152a pMDI Suspension

Caterina Antiga, University of Parma

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30

Therapeutic effect of an inhaled levodopa dry powder formulation on off episodes in patients with Parkinson’s disease

Lara de Jong, Martini Hospital

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31

Aerosol Dynamics of Sodium Chloride at High Relative Humidity

Lance Jiang, University of Bristol

 

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32

Development of a Prototype Patient Respiratory Management Mobile Health Application Using Validated Tools to Assess User Experience

Mark Nagel, Trudell Medical International

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33

Characterization of PARI’s new VORTEX® facemasks for babies and children

Andrea Winzen, PARItec GmbH

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34

On the quest to develop clinically meaningful assessment of the aerosolization performance and respirable dose of nebulization devices

Lois Slator, University of Hertfordshire

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35

Feasibility Development of Salbutamol Sulphate Pressurized Metered Dose Inhalers using a Low Global Warming Potential Propellant 1,3,3,3-Tetrafluoropropene (HFO1234ze)

Lei Mao., Recipharm Laboratories, Inc

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36

Overview of the Nonclinical Safety Program for 1,1-Difluoroethane (HFA-152a) as a Low Global Warming Potential Metered Dose Inhaler Propellant

Isaac Mohar, Gradient

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37

Spray Pattern and Plume Geometry Measurements of Current and Low GWP Propellants HFA152a and HFO1234ze(E) pMDIs With and Without Ethanol

Ben Myatt, Kindeva Drug Delivery

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38

Importance of the Tongue as an Impactor for Orally Inhaled Aerosols from a Pressurised Metered Dose inhaler (pMDI) With and Without a Valved Holding Chamber (VHC)

Mark Nagel, Trudell Medical Inernational

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39

SoundCatcher: Prediction of Inhalation Profiles and MDI Actuation Synchronization using Acoustic Emission with Machine Learning

Ellinor Nilsson, AstraZeneca

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40

Optimising Actuator Geometries of Low GWP Propellant HFA-152a Solution Formulations

Ameet Sule, Presspart Mfg Ltd

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41

Understanding fundamental formulation properties to demonstrate the feasibility of reformulating a salbutamol pMDI containing the low GWP propellant HFO1234ze(E)

Alex Slowey, Kindeva

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42

Device and formulation parameters influencing pressurised Metered Dose Inhaler (pMDI) aerosols using HFO1234ze propellant

Ben Thorne, Recipharm

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43

Physical Stability of Salbutamol Sulfate Suspensions in HFA-134a and HFO-1234ze(E)

Erik Boldt, Honeywell

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44

Stability Evaluations of Salbutamol Sulphate Propellant-Dispersible Tablets (Respitab™) for Formulation with HFA-152a.

Simon Warren, i2c Pharmaceutical Services

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45

The Effect of Elastomer Type on Stem-Diaphragm Leakage from pMDIs filled with Propellant 152a

Howard Bleazard, Kindeva Drug Delivery Limited

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46

The delivery of CRISPR-Cas9 targeting KRAS mutant in lung cancer

Siyu Chen, Ludwig-Maximilians-University Munich

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47

A New Small Molecule Effective Against Common Pathogenic Respiratory Viruses with Characteristics Optimal for Direct Delivery to the Respiratory Epithelium

David Fergenson, Livermore Instruments Inc.

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48

Pulmonary Delivery of Hybrid Polymeric Nanoparticles for Enhanced mRNA Expression

Min Jiang, Ludwig-Maximilians-Universität München

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49

Aerosol Characterization, Toxicokinetic and Biodistribution Investigations Supporting Efficient Delivery of KIT2014 Peptide to the Airways in Mice after Nose-only Inhalation

Valentina Sala, Kither Biotech

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50

Spray drying of mRNA lipoplexes to produce an inhalable dry powder formulation for mRNA therapeutics

Jana Schembera, Kiel University

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51

Inhaled ceftazidime dry powder developed using spray freeze drying technique

Rishi Shah, University of Otago

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52

Anti-biofilm activity of aerosolized phage vs. ciprofloxacin using an in vitro lung deposition platform

Mathura Thirugnanasampanthar, McMaster University

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53

Molecular Size of Linear and Branched Polyethylemine Influences the Transfection Efficacy of mRNA Polyplexes Aerosolised using a Vibrating Mesh Nebulizer

Abhimata Paramanandana, King’s College London

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54

Increases in Lipid Nanoparticle-mRNA Particle Size upon Mesh Nebulisation Vary by Aerodynamic Fraction

Hao-Ying Li, King’s College, London

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55

Evaluation of impurities, degradation products and foreign particles arising in an unwashed valved holding chamber (VHC) used with a pressurised metered dose inhaler (MDI)

Yannick Baschung, Solvias AG

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56

From formulation physicochemical properties to digital next generation impactors

Dan Hardy, Microsol

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57

Investigating Drug Loading on Stainless-Steel Mesh Filters used for Estimating Regional Lung Deposition

Alexander Huang, University of Alberta

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58

Application of HPLC-Mass Spectrometry (HPLC-MS) in Rapid Inhaler Testing

Lei Mao, Recipharm Laboratories, Inc

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59

A new paediatric airway model for in silico evaluation of regional aerosol deposition

Kineshta Pillay, University of Alberta

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60

Solid state degradation of proteins in complex drug product formulation matrices

Gerard Masdeu, AstraZeneca

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61

Flow visualisations of the spray from a novel soft mist inhaler using planar laser illumination

Vishal Chaugule, Monash University

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62

Development and Optimisation of a Particle Sizing Methodology for Early Screening of DPI Carrier Based Formulations using Laser Diffraction.

Olivia Brittain, Kindeva Drug Delivery Ltd

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63

Investigating effects of rotation speed and flow rate on powder evacuation from a capsule for dry powder inhalers

Athiya Azeem, University of Sydney

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64

Comparing protein stabilisation effects of inositol to mannitol and trehalose in inhalable particles prepared by nano spray-drying

Michael Chow, UCL School of Pharmacy

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65

QbD Assisted Development of Inhalable Spray-Dried Procubosomal Powder Intended to be used for Lung Delivery

Akash Deep, Punjabi University

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66

KuDa-tob: an Inhaled tobramycin formulation to improve treatment of Pseudomonas aeruginosa chronic lung infections for cystic fibrosis patients

Julie Movellan, CIDETEC Nanomedicine

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67

Digital tool development - Modelling Recrystallization of Amorphous Lactose.

Ingela Niklasson Björn, Astrazeneca

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68

Development of inhalable dry powders combining replication and protease inhibitors of SARS-CoV-2

Tushar Saha, University of Otago

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69

Identifying determinants of capsule emptying

Mark Sanders, Independent Researcher

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70

Impact of salts on spray dried inhaled dual site targeting mannitol powder for radiolabelling procedure

Han Cong Seow, The University of Hong Kong

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71

A new proposal for the development of sustainable generic DPI products based on respirable dose matching rather than being an exact copy of the reference

Giada Varacca, University of Parma

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72

Minimal amounts of sodium chloride combined with leucine improve aerosol performance of spray-dried vardenafil powders for inhalation

Qingzhen Zhang, University of Nottingham Ningbo China

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73

In Vitro and in Vivo Assessment of Nanoporous Amorphous Particles as a Potential Excipient for Inhaled Drug Products

Georgia Pilkington, Nanologica

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74

Regional Deposition of Spray Dried Trehalose Powders in the Alberta Idealized Nasal Inlet

Kelvin Duong, University of Alberta

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75

Use of Rheology and Mucoadhesivity to Guide the Development of Nasal Mucus Simulants

Lucy Goodacre, King’s College, London

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76

High speed video analysis for the characterisation of a jet for targeted nasal drug delivery

Alain Regard, Nemera La Verpillière

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77

Targeted drug delivery to the olfactory cleft: In vitro deposition study using prototype jet nozzles

Alain Regard, Nemera La Verpillière

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78

In Vitro Characterisation of Octreotide Microspheres Formulated for Nose to Brain Delivery

Reanne Beaird, Nanopharm Ltd, An Aptar Pharma Company

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79

An investigation of actuation forces and performance of a novel, user-independent nasal spray, based on user-device interaction

Sabrina Falloon, Recipharm

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80

Evaluation of the Performance of a Blister Unit Dose Nasal Powder Device

Gregoire Deraime, Nanopharm Ltd, An Aptar Pharma Company

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81

Investigation of the Performance of a Novel Unidose Powder Blister Device for Nasal Delivery

Cristina Rey Blanes, Nanopharm Ltd, An Aptar Pharma Company

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82

The interplay of formulation viscosity with device type and inspiratory flow provides an opportunity to target regional nasal deposition

Tsz Yan (Alice) Fong, King’s College, London

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83

High precision determination of amorphous lactose formed during comminution processes

Pauline van der Wijst-Janssen, DFE Pharma GmbH & Co. KG

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84

Development of innovative controlled released dry powders for inhalation based on budesonide for a once daily administration

Le Van Bui, Université Libre de Bruxelles

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85

Transition to renewable materials: environmental impact assessment of renewable polymers for conceptual multidose dry powder inhaler

Charlie Dean, Cambridge Consultants

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86

Automated Process Development on the Vacuum Drum Filling of DPI Formulations

Isabel Gallego, Otto-von-Guericke-University Magdeburg

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87

The role of mechanical properties in DPI Carriers

Zeredescht Majid, Kiel University

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88

Investigation and Resolution of Particle Re-entrainment in NGI Analysis of a Spray Dried Formulation Emitted from a Dry Powder Inhaler

Eric Peterson, Lonza AG

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89

High drug load and performance formulation platform for DPIs

Susana Saldanha, Hovione

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90

Impact of the blending process of carrier-based formulations on DPI performance

Luis Sousa, Hovione

 

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91

In-silico evaluation of different carrier particle geometries in interactive powder mixtures

Melvin Wostry, University of Kiel

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92

Investigating the Dispersion Capability of High Dose DPI Formulations Manufactured Through Isothermal Dry Particle Coating (iDPC™)

Jasdip Koner, Aston Particle Technologies

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93

Assessment of the Automatic Filling of Orbital™ Device Loaded with a Model High Payload Blend Manufactured by Isothermal Dry Particle Coating

Antonia Zapata, Nanopharm Ltd, An Aptar Pharma Company

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