Academy of Pharmaceutical Sciences – Workshop at DDL2022

09:00 - 09:05

Introduction

Ben Forbes, Chair

09:05 - 09:20

Nasal biopharmaceutics: current and new methods for characterisation

  • The T4N concept
  • Developments in in vitro testing of nasal products
  • Assessment of < 10 µm fraction

Regina Scherließ, Kiel University

09:20 - 09:40

Physiologically-based biopharmaceutics modelling for nasal delivery

  • Applications of PBBM modelling in nasal drug delivery
  • Current status of nasal PBBM models
  • Future opportunities/call to action

Claire Patterson, SEDA

09:40 - 10:00

Modelling deposition in the nasal cavity

  • In silico models
  • In vitro methods
  • Realistic and idealised geometries

Andrew Martin, University of Alberta

10:00 - 10:20

In vitro biopharmaceutical characterisation

  • Cell models of the nasal cavity
  • Role of mucus
  • Role of mucociliary clearance

Alison Lansley, University of Brighton

11:00 - 11:20

Preclinical models and translation

• Nasal delivery study trends
• Pre-clinical development for nasally administered medicines
• Practicalities of nasal studies and future developments in study design and           methods

Helen Palmer, Labcorp

11:20 - 11:40

Clinical development

  • Scintigraphic / MRI imaging and analysis of nasal delivery
  • Product and device performance evaluations
  • Nasal wick evaluations

Chris Roe, Quotient

11:40 - 12:00

Panel discussion

  • Gaps in biopharmaceutics for nasal delivery
  • Future directions and gap analysis:
  • Challenges and opportunities

All presenters