A Multi-Physics Theoretical and CFD Approach, To Predict Low-GWP pMDI Spray Characteristics, Inside USP-IP Geometry

A Multi-Physics Theoretical and CFD Approach,
To Predict Low-GWP pMDI Spray Characteristics, Inside USP-IP Geometry

Hossain Chizari¹, Henk Versteeg², Weeratunge Malalasekera² & Barzin Gavtash¹

¹Kindeva Drug Delivery Limited, Derby Road, Loughborough, Leicestershire, LE11 5SF, UK

²Wolfson School of MEME, Loughborough University, Ashby Road, Loughborough, LE11 3TU, UK

Summary

This paper presents the development of a comprehensive mathematical model aimed at predicting pressurized metered-dose inhaler (pMDI) unwanted drug deposition, using low global warming potential (GWP) propellant. The model incorporates various factors such as the geometric dimensions of pMDI’s actuator/valve and the properties of the formulation such as propellant, excipient, and drug load. The model successfully predicts the drug deposition on the actuator and the USP-IP, and, hence, the delivered fraction to the NGI/ACI. These predictions are validated through laboratory testing.