Development of a Mathematical Model To Estimate Droplet Size Distribution of a Pressurised Metered Dose Inhaler in the Near-Orifice Region
Hossain Chizari1, Barzin Gavtash1 , Benjamin Myatt1, Weeratunge Malalasekera2 & Hendrik K Versteeg2
1 Kindeva Drug Delivery, Derby Road, Loughborough, LE11 5SF, UK
2 Wolfson School of Mech, Elec & Man Eng, Loughborough University, Loughborough, Leics, LE11 3TU, UK
Summary
In a pMDI a range of droplet sizes will be created. In previous models, the mean droplet size was calculated and compared with PDA data. In the current study, we estimate a droplet distribution from the proposed model. This will generate more understanding of how a pMDI works and pave the path to the full model for ACI/NGI in the future.
Key Message
In this study, the droplet size distribution for any instance during a pMDI actuation is estimated, based on first principle of wave instabilities. GSD can be predicted within 5% of error in comparison with experimental data for the full range of droplets at 25mm from the spray orifice.