Baudouin Géraud, Wei Ann Yong, Caelan Anderson, Amelia Hollands, Andreas Meliniotis, Phil Swanbury
Phillips Medisize, 205 Cambridge Science Park Milton Road, Milton, Cambridge CB4 0GZ, United Kingdom
Summary
The O1 device is a unit dose dry powder inhaler platform that deagglomerates powder using a mobile cruciform ball enclosed in a cyclone chamber. It targets high lung doses through efficient delivery of large formulation nominal doses across a range of simulated patient respiratory profiles. High-speed imaging and computational fluid dynamics simulations show that the ball improves particle recovery and enhances deagglomeration by a chaotic flow. Test results show a strong performance (high fine particle dose) over a wide range of formulation fill weights.