Anna Catton1, Allen Haddrell1, Jonathan Reid1 & Joe Takher-Smith2
1University of Bristol, Cantocks’ Close, Bristol, BS8 1TS, UK
2Viatris, Discovery Park, Ramsgate Road, Kent, CT13 9ND, UK
Summary
Throughout this project, the long-term physical stability trends of dry powder formulations will be investigated, for delivery using dry powder inhalers (DPI). The focus of this project is to study the stability trends of pharmaceutical blends for dry powder formulations, particularly the long-term physical stability regarding water absorption. The long-term stability of the formulations will be determined by standard protocols which will be compared with measurements of the relative humidity response of individual particles by measuring the change in mass (resolution of 2 pg) and phase in an electrodynamic balance (EDB). The resulting mass change can be converted, to allow a comparison to be made from the rate of water uptake that these particles experience.