The barrier-forming abilities of a sodium hyaluronate formulation delivered using the PillHaler® DPI device for protection against urban dust
Juhura G. Almazi1,3, Dina M. Silva3, Valentina Trotta4, Walter Fiore5, Hui X. Ong1,2,3 & Daniela Traini1,2
1Respiratory Technology, Woolcock Institute of Medical Research, Sydney, NSW 2037, Australia
2 Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, NSW 2109, Australia
3Ab Initio Pharma Pty Ltd, 63-73 Missenden Road, Camperdown, NSW 2050, Australia. 4HollyCon Italy Pte Ltd srl, Via Danimarca 21, 20083 Gaggiano (MI), Italy. 5SOFAR Spa, Via Firenze, 40, 20060 Trezzano Rosa (MI), Italy
Summary
The pathogenesis of several bronchopulmonary diseases such as asthma, chronic obstructive pulmonary disease, acute respiratory distress syndrome and cystic fibrosis are linked to exposure to environmental pollutants such as dust, pollen, smoke, and pathogens. Thus, a comprehensive biological assessment of the protective barrier abilities against environmental pollutants (Urban Dust -UD) of a formulation of sodium hyaluronate delivered to the upper respiratory tract via the monodose PillHaler® dry powder inhaler (DPI) device was performed. Using Calu-3 cells it was demonstrated that the formulation, by forming a barrier layer, was able to prevent the direct contact of UD with the cells and in this way significantly reduced UD-induced oxidative stress and protected the epithelium from UD-induced inflammation. The protective barrier-forming abilities of the sodium hyaluronate formulation have exciting implications for preventative mechanisms against exposure to environmental hazards and resulting cardiopulmonary diseases.
Key Message
The sodium hyaluronate formulation delivered using the PillHaler® DPI device to the upper and upper lower respiratory tract (trachea and primary bronchi) has demonstrated the ability to form a physical barrier that can help to protect from the adverse effects of exposure to environmental hazards.