Andy Cooper1, Barzin Gavtash1
1 Kindeva Drug Delivery, Charnwood Campus, 10 Bakewell Road, Loughborough, Leicestershire LE11 5RB
Summary
A high force nasal pMDI has been designed which enables greater penetration and deposition of the spray within the nasal cavity. This may be useful for targeting nose-to-brain delivery via the olfactory region.
In-vitro data suggests a step change in spray penetration versus current commercial nasal pMDI products, which are less feasible for deep nasal cavity delivery. The high force and expected lower plume temperature, of the new device, may though present additional discomfort for the patient.
Further work is also required to establish the performance of the high force nasal pMDI with a range of formulations and nasal cavity geometries.
Key Message
A nasal pMDI has been designed to generate higher force than current commercial nasal pMDI products. This enables greater penetration of the spray within the nasal cavity, which may be useful for targeting nose-to-brain delivery via the olfactory region.