Inhalable Microparticles Embedding Therapeutic Calcium Phosphate Nanoparticles for Heart Targeting
Eride Quarta
University of Parma, Parma, Italy
Introduction: The aim of this work was to develop an innovative nanomedicine consisting in highly respirable microparticulate dry powder (dpCaPs) able to embed and release calcium phosphate nanoparticles (CaPs) loaded with Mimetic Peptide (11 aminoacids, 1326 Da), a therapeutic substance selectively targeting the cytosolic Cavb2 chaperon subunit of the cardiac L-type Calcium Channel Complex (LTCC) restoring cardiac function. The embedded therapeutic nanoparticles, released in deep lung by carrier dissolution upon inhalation, can target the hearth by translocation to pulmonary vein blood.