Comparison of Aerosol Delivery Efficacy by A Specially Designed T-adaptor with Vibrating Mesh Nebulizer and Existing Products in Adult Mechanical Ventilator
Chia-Chen Huang1, Hsiang-Ling Chen1, Chi-Shan Hung1, Eric Y.T. Chen1, Hui-Ling Lin2
1MicroBase Technology Corp, 756, Jiadong Road, Bade, Taoyuan, 33464, Taiwan
2Chang Gung University, 261, Wenhua 1st Road, Guishan, Taoyuan, 3302, Taiwan
Summary
Successful delivery of aerosolized medication within mechanical ventilation (MV) necessitates an efficient vibrating mesh nebulizer connected to a well-designed T-adaptor that is subsequently conjoined to the inlet of a heated humidifier in a closed ventilator circuit. The aim of this study was to compare MicroBase mechanical ventilator nebulizer plus μMVN+ (Microbase Tech. Corp., Taiwan) to currently used nebulizers during MV. A Puritan Bennet 760 ventilator was set to adult parameters (TV 600mL, 16 breaths/min, PEEP 5cm H2O) and connected to an endotracheal tube (ETT) with a filter to a passive test lung. A unit dose of salbutamol (Ventolin, 5 mg / 2.5 mL, GlaxoSmithKline) or budesonide (Pulmicort, 1.0 mg / 2.0 mL, AstraZeneca) was individually added to 5 aerosol generators, namely μMVN+4.0 (MMAD 4.0μm), μMVN+3.0 (MMAD 3.0μm), μMVN+2.0 (MMAD 2.0μm), Aerogen Solo (Aerogen Ltd., Ireland) and jet nebulizer JN (Galemed Corp.,Taiwan). All aerosol generators were placed at the inlet of a heated humidifier. Aerogen Solo was connected to the Aerogen T-adaptor and JN was connected to a standard T-adaptor. All three μMVN+ were connected to the MicrosBase Tech. Corp. second generation (MBTC-SG) T-adaptor. Drug collected on filter was eluted and analyzed with spectrophotometer at a wavelength of 276nm for salbutamol and 254nm for budesonide (n=5). The inhaled dose % of all μMVN+ which connected to MBTC-SG T-adaptor was significantly greater than Aerogen Solo and JN (p<0.001) for both drugs. Inhaled dose % of salbutamol of all devices was significantly greater than that of budesonide (p<0.001). The newly designed of μMVN+ with MBTC-SG T-adaptor enhanced aerosol drug delivery efficiency possibly by reducing aerosol impaction and condensation during nebulization.