Investigation into the in vitro Performance of Anti-static vhcs by Particle Size Distribution using the next Generation Pharmaceutical Impactor (ngi)

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Aerodynamic particle size distribution and total delivered dose (TDD) performance testing of several Anti-static Valved Holding Chambers (VHCs) has been conducted with a series of selected pMDI drugs using the Next Generation Impactor (NGI) at a flow rate of 30 L/min. The main body of the Antistatic VHCs tested is made from three distinctively different types of materials of construction – including aluminium (VORTEX Non Electrostatic Holding Chamber), Acrylonitrile Butadiene Styrene , ABS (OptiChamber Diamond Anti-static chamber) and a Polypropylene Blend Polymer (Medical Developments Internationals Anti-static Compact Space Chamber Plus & AeroChamber Plus Flow-Vu Anti-static VHC). Results have shown that the VHCs made from the polypropylene blend polymer outperform the other VHCs tested for overall TDD and FPD/EFPD deliveries over all drugs tested, with total performance ranking over all three platforms being AS-CSCP > ACP-FV > VOR-NE > OCD-AS.