Paper: Factors affecting DPI development from bench to bedsideDownload Presentation PDF
Anne Haaije de Boer is a process engineer by training and started his career in the Department of Pharmaceutical Technology and Biopharmacy of the Groningen University (NL) in 1973 where he was research leader of the inhalation group from June 1985 till November 2015. His interest is in powder formulation for inhalation, inhaler device development and aerosol characterisation. He developed the basic concepts for the Novolizer® (Meda) and Genuair® (AstraZeneca) multi-dose DPI’s, and a novel disposable dry powder inhaler platform (Twincer®) for high dose antibiotic, vaccine and protein delivery, all having air classifier technology for effective powder dispersion. The Twincer® has recently been taken into production for the administration of colistimethate sodium and a second-generation device (Cyclops) is currently in development for aminoglycosides in tuberculosis therapy and levodopa against off-periods in Parkinson’s disease. He and his co-workers also designed an inhaler adapter for aerosol characterisation with laser diffraction technique (Sympatec) and contributed to the understanding of the variables and mechanisms involved in particle interactions and powder dispersion. Anne Haaije de Boer retired on November 1st 2015, but he stays connected with the university in Groningen in order to further develop the Twincer® disposable high dose dry powder inhaler platform.